Clinical study of an amine fluoride gel and acidulated phosphate fluoride gel

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Abstract
Caries inhibition was compared in children by an amine fluoride and an acidulated phosphate fluoride when administered in a topically applied gel. The effects of applying amine fluoride daily and weekly were compared. Children (468), agest 6-13, were randomly assigned to 1 of 5 treatment groups and received a total of 5, 5 min treatments. The treatment and interval between each of the 5 treatments were acidulated phosphate fluoride daily, amine fluoride daily, amine fluoride weekly, placebo daily and placebo weekly. When the children were examined for total Decayed, Missing and Filled Surfaces (DMFS) increments 2 yr later, no significant differences were observed. When the data were examined for effects on DMFS for a specific tooth surface, significant restriction (61%) of occlusal increment was shown in the group which was treated with amine fluoride daily for 5 consecutive days as compared with the control group.