Synthesis of β-amino-acid peptides by aminolysis of substituted di-hydro-1,3-oxazinones and amino-protected β-lactams
- 1 January 1973
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- p. 2001-2006
- https://doi.org/10.1039/p19730002001
Abstract
A number of standard peptide coupling methods failed when applied to sterically hindered derivatives of 3-amino-3-methylbutanoic acid. Di- and tri-peptides were made by aminolysis of dihydro-1.3-oxazinones and by this method in conjunction with the pivaloyl mixed anhydride method. N-Protected azetidin-2-ones were found to have limited application in β-amino-acid peptide synthesis.Keywords
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