Oxandrolone Therapy in Growth Retardation of Children

Publisher Website
Google Scholar
Abstract
DURING the past 25 years various investigators have used testosterone and its analogues to accelerate growth in short-statured children. Although in all cases a definite growth spurt was achieved,1-12the clinical reports concerning the effect of testosterone in acceleration of osseous maturation have been rather controversial.2-5,9,11,12The results of some studies2,3,12indicated that there was undue acceleration of osseous maturation and sexual development as compared to linear growth and chronologic age (CA). Further investigations4,5,9,11suggested that these untoward effects might be avoided when small to moderate doses of testosterone were used. Despite these reports, however, opinion concerning testosterone and its analogues as growth-promoting agents has continued to be guarded.12 In the past few years, several anabolic steroids have been synthesized in an attempt to minimize virilizing properties while retaining the anabolic effect. Clinical studies on these synthetic anabolic steroids have been carried out. Although growth

This publication has 1 reference indexed in Scilit: