Effect of thyroidectomy, and thyroxine and α2u-globulin replacement therapy on testicular steroidogenic and gametogenic activities in rats

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Abstract
Adult male rats were thyroidectomized and killed after 22 days of treatment. Thyroidectomy lowered the weights of testes and accessory sex organs, decreased the activities of testicular Δ5-3β- and 17β-hydroxysteroid dehydrogenases (HSD), and diminished spermatogenesis, serum levels of testosterone and α2u-globulin. Supplementation with thyroxine at a dose of 5 μg/100 g body weight per day for 21 days or supplementation with α2u-globulin at a dose of 1·5 mg/rat per day for 21 days in thyroidectomized animals partially reversed the decrease in HSD activities and serum concentrations of testosterone and α2u-globulin, while spermatogenesis was restored to normal. The weights of testes and accessory sex organs were also reinstated after supplementation with thyroxine or α2u-globulin in thyroidectomized rats in comparison with thyroidectomized animals. It was concluded that α2u-globulin may be an intermediary in the thyroid hormone control of testicular function. Journal of Endocrinology (1994) 140, 343–347

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