Narcolepsy

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Abstract
NARCOLEPSY, a syndrome of excessive sleepiness and abnormalities of rapid-eye-movement (REM) sleep,1 is a distinct neurologic disorder with characteristic clinical symptoms and sleep-laboratory findings. Narcolepsy associated with cataplexy is often called "classic narcolepsy." There have been several important advances in understanding narcolepsy since the last review in the Journal.2 Narcolepsy is strongly linked to certain Class II HLA antigens, indicating the presence of a "narcolepsy-susceptibility" gene on chromosome 6. Pharmacologic and pathological studies of human and canine narcolepsy have demonstrated abnormalities of monoaminergic and cholinergic functioning in the brain. The objective assessment of sleepiness and the onset of REM . . .

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