Conformational analysis of hexahydro-3H-oxazolo[3,4-c]pyridines by carbon-13 fourier-transform nuclear magnetic resonance spectroscopy
- 1 January 1974
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 6,p. 210-211
- https://doi.org/10.1039/c39740000210
Abstract
Comparison of the C(3), C(1), and C(8a) chemical shifts in hexahydro-3H-oxazolo[3,4-c]pyridine with those in anancomeric derivatives suggests its existence in solution at n.m.r. probe temperature as a cistrans equilibrium mixture containing ca. 76% of the trans-fused conformation; 13C–H coupling constants involving the C(3) protons are dependent upon the orientation of adjacent lone pairs.Keywords
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