Lack of Relation of Oral Clefts to Diazepam Use in Pregnancy

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Abstract
To the Editor: We were interested to see the report by Rosenberg et al. (Nov. 24 issue)* that attempted to relate the risk of congenital oral clefts to the use of diazepam in the first trimester of pregnancy. It strikes us that their choice of control group seriously compromises their conclusion that diazepam use is not associated with this specific congenital anomaly. Without a valid estimate of frequency of diazepam use in a control group of women who had normal babies, the best conclusion supported by their data is that diazepam is no more implicated in the production of clefts . . .

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