Some Studies on Acute Inflammation Induced by Dextran in the Mouse

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Abstract
Intravenous dextran resulted in acute pinnal inflammation in all strains of mice examined, although the incidence of reactivity differed between strains. With ASL/TO mice, dextran produced a dose-dependent inflammatory response followed by a refractory state. Breeding experiments showed that the incidence of reactivity in this strain is not controlled by simple Mendelian laws of inheritance. Anti-histamines, anti-5-hydroxytryptamines, D-glucose, 2-deoxy-d-glucose, cortisone, catecholamines and methylthiouracil inhibited the reaction as did large doses of disodium cromoglycate and non-steroidal anti-inflammatory agents. The pinnal response was enhanced by deoxycorticosterone, adrenalectomy and 1-thyroxine while insulin was without effect. No pinnal reaction occurred after the intravenous injection of egg-white or dextrin but in all mice tested compound 48/80 induced an inflammatory response which was dose-dependent. The relationship of these findings to the anaphylactoid reaction in rats and to urticarial states in man is discussed.

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