Transaminase inhibitors block glycolysis and G1 to S phase progression in chick embryo fibroblasts: Reversal by α‐keto acids

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Abstract
Two transaminase inhibitors, aminooxyacetate and cycloserine, inhibited the initiation of insulin-stimulated DNA synthesis in chick embryo fibroblasts. This inhibition was overcome when pyruvate (4 mM), oxaloacetate (4 mM), or α-ketobutyrate (10 mM) was included in the culture medium with hormone and inhibitor. Aminooxyacetate also inhibited lactate production in insulin treated cultures in the absence of added α-keto acid.