Effective Lipid Modification by Partial Ileal Bypass Reduced Long-term Coronary Heart Disease Mortality and Morbidity: Five-Year Posttrial Follow-up Report From the POSCH

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Abstract
THE PROGRAM on the Surgical Control of the Hyperlipidemias (POSCH) was a multiclinic, randomized, prospective, secondary intervention trial designed to ascertain whether the effective reduction of plasma total cholesterol and low-density lipoprotein (LDL) cholesterol levels and the increase of the plasma high-density lipoprotein (HDL) cholesterol levels induced by the partial ileal bypass operation had a favorable impact on overall mortality and the mortality and morbidity attributable to atherosclerotic coronary heart disease (ACHD). The Program on the Surgical Control of the Hyperlipidemias was both a clinical and arteriographic end points trial, the first atherosclerosis intervention trial to correlate changes observed on sequential coronary arteriograms with clinical atherosclerotic events.

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