CHANGES IN HYPOTHALAMIC NORADRENALINE, DOPAMINE AND SEROTONIN UPTAKE AFTER OESTRADIOL ADMINISTRATION TO RATS

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Abstract
Estradiol treatment increased dopamine uptake by the anterior hypothalamus to the extent of 29 and 112% at 11.00 and 17.00 h, respectively. Serotonin uptake by the anterior and posterior hypothalamus was augmented by estradiol to 145 and 98% at 11.00 h concomitantly with a 55 and 34% increase of norepinephrine [NE] upatke by the medial basal and posterior hypothalamus, respectively. Significant differences in NE and serotonin uptake by the posterior hypothalamus were observed in vehicle-treated rats killed at 11.00 and 17.00 h, suggesting the existence of diurnal variations in neurotransmitter uptake. Essentially similar results to those reported above were found in a 2nd series of experiments. An activation by estradiol of neurotransmitter re-uptake mechanisms in hypothalamic monoaminergic neuron preceding gonadotropin and prolactin release is supported.