TOLERANCE OF THE NEWBORN TO ANOXIA

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Abstract
A study of the tolerance to anoxia of the adult and infant of various spp.: rat, dog, cat, rabbit, and guinea pig. Anoxia was produced by the respiration of N, nitrous oxide, He, CO2, and cyclopropane and submersion in water. The newborn exhibits an extraordinary tolerance in comparison with the mature animals of the same sp. The period of tolerance is not the same in the various spp. studied, being longest in the physiologically immature new-born rat and shortest in the comparatively mature guinea pig. Among the factors permitting survival of the newborn rat and puppy is poikilothermia, a fall of temp. diminishing the metabolic demands. Another factor is the lower cerebral metabolic rate demonstrated in the rat and dog. Fetuses delivered from mothers who had succumbed to anoxia produced by inhalation of 5% O2 in nitrous oxide or the inj. of cyanide respired spontaneously on delivery and some were raised by foster mothers.

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