Synthesis of 25-hydroxycholesterol from 3β-hydroxyandrost-5-en-17-one. A method for stereospecific construction of a sterol side-chain
- 1 January 1975
- journal article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 24,p. 968-969
- https://doi.org/10.1039/c39750000968
Abstract
The side-chain of 25-hydroxycholesterol was constructed stereospecifically on the androstane skeleton via addition of an ethyl acetate unit to C-17 and sub-sequent alkylation of the resulting ester C-20 with a C5 unit; the remaining carbon atom (C-27) was added by a Grignard reaction.Keywords
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