Effect of Drugs and Insecticides on the Anesthetic Action of Steroids

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Abstract
The chronic administration of drugs and insecticides such as phenobarbital, chlorcyclizine, phenyl-butazone, chlordane and DDT to rats markedly decreases the central depressant effects of administered steroid hormones. This decrease in the pharmacological effect of steroids is correlated with the previously reported increase in the metabolism of steroid hormones in vitro caused by chronic drug and insecticide treatment. Although this correlation exists, other possible explanations for the decreased central action of steroids caused by chronic drug treatment, such as an effect on the uptake of the steroid into the brain, should be considered.