Metabolism of 3-(2′,4′,5′-Triethoxybenzoyl)propionic Acid, a New Biliary Smooth Muscle Relaxant with Choleretic Activity: II. Metabolism after Repeated Dosing in Rats, in Relation to Choleretic Activity

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Abstract
1. Accumulation and possible induction in the metabolism of treithoxybenzyolpropionate were studied in rats in relation to the choleretic effect of the drug. Daily oral administration of [14C]triethoxybenzoylpropionate showed no accumulation of drug or metabolites. Pre-treatment of rats with the drug did not induce its own metabolism or the metabolism of aminopyrine, p-nitroanisole, hexobarbital or zoxazolamine. 2. Choleresis in rats induced by triethoxybenzoylpropionate resulted from enhanced formation of the bile acid-independent fraction of canalicular origin. presumably mediated by the increased transfer of sodium into the canaliculi. This was not altered by repeated pre-treatment with the drug, in accordance with the metabolic findings.