Transactivation joins multiple tracks to the ERK/MAPK cascade
Top Cited Papers
- 1 August 2003
- journal article
- Published by Springer Nature in Nature Reviews Molecular Cell Biology
- Vol. 4 (8) , 651-657
- https://doi.org/10.1038/nrm1173
Abstract
Many agonists of G-protein-coupled receptors (GPCRs) can stimulate receptor tyrosine kinases and the extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) pathway. A 'transactivation' mechanism, which links these events in one signalling chain, inspired many researchers, but inevitably raised new questions. A 'multi-track' model for GPCR signalling to the ERK/MAPK pathway might resolve some of the puzzles in the transactivation field.Keywords
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