A Clinical Study of Antimicrobial Agents Delivered to Burn Wounds from a Drug-loaded Synthetic Dressing

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Abstract
The release of antimicrobial agents from a solid barrier dressing when applied to 2nd- and 3rd-degree burn wounds was investigated. The synthetic dressings were formed by a mixture of polyethylene glycol-400 (PEG), poly-2-hydroxethyl methacrylate (PHEMA) and 1 of the test drugs: silver sulfadiazine (AgSD), gentamicin, silver nitrate or nitrofurazone. The dressings were formed directly on the burn wounds of 33 patients from a paste prepared from a mixture of PEG-PHEMA and drug. These dressings remained in place for 3 days, covering 12-64 in.2 of the wound. In 6 patients, the entire burn wounds were covered with the dressings: the treated areas were .apprx. 200 in.2. The use of drug-loaded synthetic dressings extended to cover major portions of the burn wounds reduced the work required for nursing care and lessened patient discomfort.

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