The Effect of Foster Nursing on the Growth of a Transmissible Leukemia in Mice

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Abstract
A lymphoid leukemic tumor induced in a Jax dilute brown strain (D), subline 212, mouse when transplanted to this same strain grew in 4 of 6 in the first generation and 100% in the following 6 transplant generations. The tumor grew in only 1 of 41 D strain, subline 111, mice and none of 26 Jax C57 black strain (B) mice. Of 12 D strain, subline 111, mice foster nursed by a D, subline 212, mother 6 were positive to inoculations in the first generation transfer. All resistant D strain mice fostered by a susceptible D mother were positive to fourth generation inoculations. All B strain mice fostered by a susceptible D strain mother grew leukemic cells of the fourth generation transfer. Leukemic cells which grew in resistant fostered hosts failed to grow when reinoculated into resistant non-fostered mice. Expts. are in progress to test the reaction of susceptible D strain mice deprived entirely of "susceptible" milk. All mice removed within 12 hrs. following birth and fostered on a resistant B strain mother grew leukemic cells.

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