Spectral Assignment and Cytotoxicity of 22-Hydroxytingenone fromGlyptopetalum sclerocarpum
- 31 July 1990
- journal article
- research article
- Published by Georg Thieme Verlag KG in Planta Medica
- Vol. 56 (04) , 380-382
- https://doi.org/10.1055/s-2006-960988
Abstract
22-Hydroxytingenone was reisolated from a new source, Glyptopetalum sclerocarpum M. Laws and, for the first time, its unambiguous 13C-NMR assignments were accomplished through the use of APT, HETCOR, and selective INEPT spectroscopy. Intense, but nonspecific cytotoxic activity was observed when this substance was evaluated with a battery of cell lines comprised of the P-388 lymphocytic leukemia, KB carcinoma of the nasopharynx, and a number of human cancer cell types, i.e. HT-1080 fibrosarcoma, LU-1 lung cancer, COL-2 colon cancer, MEL-2 melanoma, and BC-1 breast cancer.Keywords
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