Cytotoxic Polyacetylenes from the Twigs of Ochanostachys amentacea
- 12 January 2001
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 64 (2) , 246-248
- https://doi.org/10.1021/np000484c
Abstract
Bioassay-guided investigation of the twigs of Ochanostachys amentacea using LNCaP (hormone-dependent human prostate cancer) cells as a monitor led to the isolation of three alkynes, the known (S)-17-hydroxy-9,11,13,15-octadecatetraynoic acid (minquartynoic acid, 1) and two novel analogues, (S)-17,18-dihydroxy-9,11,13,15-octadecatetraynoic acid (2) and (S)-17-hydroxy-15E-octadecen-9,11,13-triynoic acid (3). Compounds 1−3 were tested against a panel of human tumor cell lines and found to be significantly cytotoxic.Keywords
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