Is Prolactin Mitogenic for Mammary Epithelium?
Open Access
- 1 July 1972
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 69 (7) , 1693-1696
- https://doi.org/10.1073/pnas.69.7.1693
Abstract
Prolactin administration to mature virgin mice leads to prolilferation of epithelium of the mammary gland. In organ culture, prolactin is not mitogenic, but insulin and insulin-free serum are. These observations are reconciled by the finding that insensitive epithelium is sensitized to insulin and/or serum by prolactin treatment in vivo. Thus, it appears that prolactin acts indirectly as a mitogen by rendering the cells susceptible to the aforementioned mitogens.Keywords
This publication has 16 references indexed in Scilit:
- Serum Levels of Prolactin, Luteinizing Hormone, and Follicle Stimulating Hormone During Pregnancy in the Rat1Endocrinology, 1972
- Stimulation of Mammary Epithelial Cell Proliferationin Vitroby Protein Factor (s) Present in SerumEndocrinology, 1971
- Morphogenic and Mitogenic Effects of Prolactin on Rat Mammary Glandin VitroEndocrinology, 1971
- Glucocorticoid Regulation of ACTH Sensitivity of Adenyl Cyclase in Rat Fat Cell MembranesProceedings of the National Academy of Sciences, 1970
- BIOCHEMICAL CHANGES DURING DEVELOPMENT OF MOUSE MAMMARY TISSUE IN ORGAN CULTUREJournal of Endocrinology, 1970
- Protein and Nucleic Acid Synthesis in Rat Mammary Glands During Early Lactation1Endocrinology, 1968
- DIVISION OF BIOCHEMISTRY: MULTIPLE HORMONE INTERACTIONS RELATED TO THE GROWTH AND DIFFERENTIATION OF MAMMARY GLAND IN VITRO*Transactions of the New York Academy of Sciences, 1968
- Adenohypophysis: ProlactinAnnual Review of Physiology, 1966
- Hormone-dependent differentiation of mammary gland in vitro.Proceedings of the National Academy of Sciences, 1965
- The hormonal control of mammary growth and lactation.1958