Hydrogen bonding and cooperativity effects on the assembly of carbohydrates

Abstract
The effect of intramolecular hydrogen bonds on the cooperative assembly of carbohydrate derivatives has been evaluated; the 1,3-diaxial OH···OH intramolecular hydrogen bond is at the origin of the dimerization of diol 1; and one intermolecular OH···OH bond accounts for 2.5 kcal mol 1 in CDCl3 and 3 kcal mol–1 in CDCl3–CCl4.

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