Relation of Prothrombin Concentration to Bleeding during Oral Anticoagulant Therapy

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Abstract
The fact that unsuspected organic lesions may bleed during anticoagulant therapy has been emphasized by others.1 2 3 4 5 6 The physician faced with hemorrhage occurring in a patient receiving anticoagulant drugs must therefore decide whether search for an occult pathologic process is warranted. This problem may prove as vexing as the management of the bleeding.To study this matter, the records of the Anticoagulant Unit of the University Hospital for 1947–1960 were examined, and the complete hospital charts of all patients who were reported to have bled during treatment were then obtained for review. Isolated episodes of minor bleeding (minor epistaxis, minor dental . . .