In vitro megakaryocyte colony formation in patients with idiopathic thrombocytopenic purpura: Differences between acute and chronic ITP

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Abstract
In vitro megakaryocyte colony formation from the bone marrow of patients with acute idiopathic thrombocytopenic purpura (ITP) or chronic ITP was compared using a plasma clot system. The number of megakaryocyte colony‐forming units (CFU‐Meg) was significantly higher (p < 0.05) in acute ITP compared to chronic ITP (54.3 ± 68.4 vs. 12.9 ± 15.3/105 nonadherent mononuclear cells, mean ± SD), and significantly lower (p < 0.05) in chronic ITP compared to controls (12.9 ± 15.3 vs. 22.8 ± 15.9). A significant correlation was observed between platelet recovery 7 and 30 days after culture, and the number of CFU‐Meg (r = 0.49 and 0.45, respectively, p < 0.05). An inverse correlation was observed between platelet count at the time of culture and the number of Megs per colony (r = ‐0.48, p < 0.05). These results indicated a difference between acute and chronic ITP in the ability to promote in vitro Meg colony formation and may suppose a different immune mechanism for thrombocytopenia in these two disorders.

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