β-GLUCURONIDASE ACTIVITY IN THE RAT UTERUS1

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Abstract
During the estrous cycle of the rat no change in the uterine beta-glucuronidase activity was found. A decrease in beta-glucuronidase activity was not observed before 8-12 days following ovariectomy; a further decrease in the enzyme level occurred without a concomitant decrease in uterine wt. A single injn. of estradiol ben-zoate into ovariectomized rats resulted in a consistent although not statistically significant decrease in enzyme activity and in an increase in uterine wt. 12 hrs. after estrogen admn. This was followed by a gradual rise in enzyme concn., which reached a significantly higher level 48 hrs. after the injn. Prolonged estrogen treatment of castrated rats increased the enzyme level slightly, but significantly, above that of normal intact rats.