SKIN RASH HEPATITIS + HEMOLYTIC ANEMIA CAUSED BY PARA-AMINOSALICYLIC ACID

1 January 1964

journal article
research article
Published by Elsevier

Vol. 89 (3) , 440-+
https://doi.org/10.1164/arrd.1964.89.3.440

Abstract

A case of hypersensitivity to para-aminosalicylic acid (PAS) is reported. The reaction consisted of fever and generalized skin rash followed by intense jaundice and severe hemolytic anemia. Lymphadenopathy, hepato-splenomergaly, and ascites were present. Liver biopsies revealed a reversible type of intrahepatic cholestasis as well as some liver cell damage. Function tests indicated both hepatocellular and obstructive elements. Eosinophilia and atypical lymphocytosis were also present. Recovery was complete. The combined complication of toxic hepatitis and hemolytic anemia due to PAS has not been reported previously in the English literature.

Keywords

This publication has 1 reference indexed in Scilit:

COMBINED HYPERSENSITIVITY REACTION TO SODIUM PARA-AMINOSALICYLATE AND ASSOCIATED ANTIBACTERIAL DRUG CONCURRENTLY ADMINISTERED
Annals of Internal Medicine, 1957