The Acidic Microclimate in Poly(lactide-co-glycolide) Microspheres Stabilizes Camptothecins
- 1 January 1999
- journal article
- Published by Springer Nature in Pharmaceutical Research
- Vol. 16 (2) , 241-248
- https://doi.org/10.1023/a:1018876308346
Abstract
Purpose. The camptothecin (CPT) analogue, 10-hydroxycamptothecin (10-HCPT) has been shown previously to remain in its acid-stable (and active) lactone form when encapsulated in...Keywords
This publication has 6 references indexed in Scilit:
- Two‐photon fluorescence lifetime imaging microscopy of macrophage‐mediated antigen processingJournal of Microscopy, 1997
- Stabilization of 10-Hydroxycamptothecin in Poly(lactide-co-glycolide) Microsphere Delivery VehiclesPharmaceutical Research, 1997
- Lipid bilayer partitioning and stability of camptothecin drugsBiochemistry, 1993
- A kinetic and Mechanistic Study of the Hydrolysis of Camptothecin and Some AnaloguesJournal of Pharmaceutical Sciences, 1992
- Development of poly(ortho esters): a historical overviewBiomaterials, 1990
- Modification of the hydroxylactone ring of camptothecin: inhibition of mammalian topoisomerase I and biological activityJournal of Medicinal Chemistry, 1989