Enhanced immunogenicity of xenogenized tumor cells in rats pretreated with cyclophosphamide.

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Abstract
Immunization with xenogenized tumor cells, tumor cells infected with murine leukemia viruses, produced strong antitumor immunity. In this study, the immunogenicity of xenogenized tumor cells was compared in cyclophosphamide-treated and non-treated rats. CY treatment 3 days before immunization with xenogenized tumor cells enhanced antitumor cell-mediated immunity and antibody responses. However, CY treatment after immunization had no effect. Transfer of thymus cells form normal rats before the tumor challenge abolished the CY-induced augmenting effect. From these results, it is suggested that the elimination of precursors of suppressor T-cells by CY treatment results in enhanced immunogenicity of xenogenized tumor cells.

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