Role of IGF-I in muscular atrophy of aging
- 1 August 1997
- journal article
- review article
- Published by Springer Nature in Endocrine
- Vol. 7 (1) , 61-63
- https://doi.org/10.1007/bf02778065
Abstract
Loss of muscle mass and strength are well-known consequences of aging. The growth hormone/IGF-I pathway is both impaired with aging and essential for growth and maintenance of skeletal muscle. Despite this, growth hormone (GH) replacement has not been effective in increasing muscle mass and strength in the elderly. Possible explanations for this failure includeKeywords
This publication has 9 references indexed in Scilit:
- Growth Hormone Replacement in Healthy Older Men Improves Body Composition but Not Functional AbilityAnnals of Internal Medicine, 1996
- Effects of recombinant insulin-like growth factor-I and growth hormone on bone turnover in elderly womenJournal of Bone and Mineral Research, 1995
- The effects of recombinant human insulin-like growth factor-I and growth hormone on body composition in elderly women.Journal of Clinical Endocrinology & Metabolism, 1995
- Effect of growth hormone and resistance exercise on muscle growth and strength in older menAmerican Journal of Physiology-Endocrinology and Metabolism, 1995
- Effect of recombinant human growth hormone on the muscle strength response to resistance exercise in elderly men.Journal of Clinical Endocrinology & Metabolism, 1994
- The Insulin-Like Growth Factor I Generation Test: Resistance to Growth Hormone With Aging and Estrogen Replacement TherapyHormone and Metabolic Research, 1994
- Human Growth Hormone and Human AgingEndocrine Reviews, 1993
- Growth hormone treatment in growth hormone-deficient adults. I. Effects on muscle mass and strengthJournal of Applied Physiology, 1991
- Effects of Human Growth Hormone in Men over 60 Years OldNew England Journal of Medicine, 1990