Hormonal Modification of the Distribution of 1-Amino-cyclopentanecarboxylic Acid-l-C14in the Rat

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Abstract
Four hormones have been examined for their ability to alter the distribution in the rat of the new model amino acid, l-aminocyclopentanecarboxylic acid-l-C14. Although the total tissue concentrations of this amino acid were considerably less than those found previously for α-aminoisobutyric acid, the changes produced by the hormones were much the same for both amino acids. Hydrocortisone elevated the liver level of 1-aminocyclopentanecarboxylic acid within 2 hr. Bovine growth hormone accelerated entry of the amino acid into both skeletal muscle and liver of hypophysectomized rats within 1 hr. Testosterone propionate elevated its distribution ratio in the kidney but not in skeletal muscle, whereas β-estradiol significantly increased uptake of the model amino acid only by the immature uterus. Only growth hormone produced a significant change in the serum level of l-aminocyclopentanecarboxylic acid under the conditions used.