T cell immunodominance and maintenance of memory regulated by unexpectedly cross-reactive pathogens
- 3 June 2002
- journal article
- research article
- Published by Springer Nature in Nature Immunology
- Vol. 3 (7) , 627-634
- https://doi.org/10.1038/ni806
Abstract
We show here that T cell cross-reactivity between heterologous viruses influences the immunodominance of virus-specific CD8+ T cells by two mechanisms. First, T cells specific for cross-reactive epitopes dominate acute responses to viral infections; second, within the memory pool, T cells specific for cross-reactive epitopes are maintained while those specific for non-cross-reactive epitopes are selectively lost. These findings suggest an immunological paradigm in which viral infections shape the available T cell repertoire, causing alterations in the hierarchies of both the primary and memory CD8+ T cell responses elicited by subsequent viral infections. Thus, immunodominance is a function of the host's previous exposure to unrelated pathogens, and this may have an impact on protective immunity and immunopathology.Keywords
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