Newborn Siblings in Families Known to Have Hereditary Disorders

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Abstract
DURING RECENT YEARS notable advances have been made in the prevention of mental retardation; particularly in the cases of phenylketonuria and galactosemia, detection, treatment, and management of the disorders have been improved. Early detection, followed by prompt and careful treatment, may prevent the severe mental retardation usually associated with both of these metabolic defects. It is particularly important that knowledge gained by research workers be brought to the attention of physicians who may first come in contact with the affected children. The management of newborn siblings of patients with phenylketonuria or galactosemia presents a special and immediate problem. Both conditions are inherited as a recessive trait. The risk to subsequent siblings in a family in which the disease is known to be present is 1 chance in 4, in contrast to the relatively low incidence in the general population. To obtain the best regimen for management of these "high-risk" individuals,

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