Metabolism of Hydrazine

Abstract
A method for measuring nitrogen-15 expired by rats following administration of nitrogen-15-labeled substrates has been devised. Measurement sensitivity was below 10 micromoles nitrogen-15 produced over a 24 hour period. Studies of the metabolic disposition of nitrogen-15-hydrazine indicated that over a 48 hour period about 25% of a single, 1 mmole/kg dose was converted to nitrogen-15. Urinary hydrazine accounted for almost 29% of the dose over 48 hours, and a hydrolyzable derivative(s) of hydrazine accounted for about 24%; total respiratory and urinary excretion accounted for about 75% of the dose. In the blood, both components were measurable for at least 24 hours. The derivative is thought to be mono- or diacetylhydrazine but identification has not been clearly established. Measurements during continuous infusion of hydrazine showed that at dose rates below 0.167 mmole/kg/hour, blood hydrazine usually reached a steady state proportional to input rate.

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