Treatment of Respiratory Acidosis with N-Allylnormorphine (Nalline)

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Abstract
IN 1943 Unna1 first reported the results of animal studies on the antagonistic properties of N-allyl-normorphine (Nalline) to morphine. In recent years, the therapeutic application of these properties has been under investigation in human subjects.2 3 4 Nalline is chemically related to morphine by the substitution of an allyl bromide group in the morphine radical.1 , 5 It counteracts the toxic effects of morphine in animals, especially the depression of respiration, and in some animals it apparently serves as a mild analgesic drug.1 In human beings it not only has no demonstrable analgesic activity in itself but also abolishes the analgesic effects of morphine . . .