Salmonella typhiin the Past Decade: Learning to Live with Resistance

Abstract
Sir—Salmonella typhi, the agent that causes enteric fever, continues to be the isolate most frequently associated with community-acquired bacteremia at our institute (a tertiary care center in Mumbai, India). For decades, chloramphenicol was the antibiotic of choice for treatment of enteric fever, but the widespread emergence of S. typhi with plasmid-mediated resistance to multiple drugs, including chloramphenicol, cotrimoxazole, and amoxicillin, necessitated the search for other options. Such resistance is conferred by the presence of a 100-megadalton plasmid.

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