Within a two-year period, three cases of Hodgkin's disease complicated bySalmonella typhimuriuminfection were seen. Patients with Hodgkin's disease characteristically suffer from a defect in cellular immunity. Since this type of immunity appears to be important in the defense againstSalmonella, it is suggested that patients with Hodgkin's disease may be particularly susceptible to infection by these organisms. Other possible contributing factors are the presence of masses of neoplastic tissue and hemolysis. It is important to recognize this association and to consider salmonellosis among the possibilities in patients with Hodgkin's disease suffering a superimposed febrile illness.