Development of Cortisol Binding in the Rhesus Monkey†

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Abstract
The in vitro concentration of cortisol (μg/100 ml plasma) that was bound to corticosteroid-binding globulin (CBG) was measured at weekly intervals in rhesus neonates from birth until 4 months postpartum and on one occasion in 1-, 2-, 3-, 4-, and S-year-old monkeys. The binding capacity of CBG (CBGBC) of newborns ranged from 5 to 10 μg/100 ml plasma; that of older neonates and of monkeys up to 2 yr old fluctuated between 12 and IS μg/100 ml plasma. Adult levels of CBGB0 (20-25 μg/100 ml plasma) were observed in 3-, 4-, and 5-yr-old animals. The age at which these animals reached adult CBGB0 levels coincides with the approximate age at which monkeys born and reared at this facility attain sexual maturity. Daily injections of estrogen stimulated highly significant increases in the CBGBC and cortisol levels of both male and female neonates. However, the same treatment did not affect these parameters in adult male rhesus. No sex difference in the CBGBC or cortisol levels of neonates was found during control or estrogen treatment periods. The rhesus neonate appears to be a suitable model for further study of the endocrine regulation of CBG in primates. (Endocrinology93: 363, 1973)

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