Gastric secretion in relation to mucosal blood flow studied by a clearance technic.

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Abstract
The relationship between secretion and mucosal blood flow was investigated in the stomach of unanesthetized dogs provided with denervated pouches. Gastric mucosal blood flow was estimated by aminopyrine clearance. Secretion and mucosal blood flow were studied during administration of varying amounts of histamine or porcine gastrin, and of combinations of these stimuli with bethanechol, vasopressin, isoproterenol, epinephrine, or secretion. Under all conditions of stimulation and inhibition, clearance varied directly with secretory rate; however, for some situations (e.g., isoproterenol plus histamine) mucosal blood flow per unit of secretion was higher than for other situations (e.g., vasopressin plus histamine). From these findings we conclude that secretion and mucosal blood flow are related in the stomach.