In vivo induction of tumor‐specific immunity by glycolipid extracts of SV40‐transformed cells

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Abstract
Glycolipid extracts were prepared from various Syrian golden hamster cell lines, either SV40‐transformed or spontaneously transformed. To detect possible SV40‐TSTA activity of the glycolipid preparations, normal hamsters were inoculated with different glycolipid extracts and were subsequently challenged with an SV40 tumor‐cell line. Significant immunoprotection against SV40 tumor challenge was induced with glycolipids obtained from SV40‐transformed cell lines. This was expressed as complete tumor rejection or as a decrease in tumor growth rate, when compared to controls. No protective effects were induced with glycolipid extracts from spontaneously transformed cells. Results suggest that tumor‐specific glycolipids synthesized in cells transformed by SV40 virus could act as tumor transplantation antigens responsible for specific tumor rejection in syngeneic hosts.

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