Immune complexes in diabetes insipidus syndrome of rabbits immunized with vasopressin.

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Abstract
Rabbits immunized with lysine-vasopressin bovine serum albumin conjugate showed the diabetes insipidus syndrome intermittently, manifested by polyuria and polydipsia with various degrees of peaking from the 8th-14th day postinjection during boosters. The antibody-antidiuretic hormone immune complexes which may interfere with the action of the endogenous vasopressin on the kidney were found in the diabetes insipidus rabbits. The degree of the polyuria was not necessarily related to the quantities of the formed immune complexes, the titer, nor the affinity of the antiserum. The degree of the polyuria is probably related not only to the binding ability of the antiserum to the endogenous vasopressin, but also to other factors.

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