The Diagnostic Value of Serum Copper/Zinc Ratio in Gynecological Tumors

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Abstract
Serum Cu levels (SCu) and serum Zn levels (SZn) were determined on admission in 73 women hospitalized for suspected gynecological tumor. Twenty-five of the women were subsequently found to have malignant tumor, while 48 had benign growths. The serum Cu/Zn ratio of the malignant group (2.13 .+-. 0.53) was significantly (P < 0.001) higher than that of the benign group (1.45 .+-. 0.25). A good correlation was established between the Cu/Zn ratio and the stage of the malignant tumor. Serum Cu level showed a linear correlation (r = 0.878) with serum ceruloplasmin values. The serum Cu/Zn ratio may be used as a valuable predictor of the presence of malignant gynecological tumor and its stage.