Human Leukocyte Antigen Alleles and Haplotypes Associated with Selective Immunoglobulin A Deficiency in Spanish Pediatric Patients

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Abstract
Class I and II human leukocyte antigens were determined by a standard microlymphocytotoxity test in a group of 45 pediatric patients with selective immuno-globulin A deficiency (IgA-D), 33 of them with frequent respiratory tract infections, allergic diseases, or gastrointestinal disorders (RTIAG), and 12 with celiac disease (CD). The results showed that the DR1 allele, and the A1,B8,Cw7,DR3,DQw2; B35,Cw4,DR1,DQw1; and B14,DR1,DQw1 haplotypes could be involved with IgA-D susceptibility in RTIAG patients. Among the CD-IgA-D group, the B14 allele and A1,B8,Cw7,DR3,DQw2 haplotype were found to confer a high risk of developing IgA-D. A possible protective role may be postulated for DR2 and DR4 in both types of IgA-D patients. The present study confirms some of the previous findings in other white populations and describes new possible alleles and haplotypes that could be implicated with IgA-D susceptibility and resistance.

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