TRAUMATIC SHOCK. VII. A STUDY OF THE PROBLEM OF THE “LOST PLASMA” IN HEMORRHAGIC, TOURNIQUET, AND BURN SHOCK BY THE USE OF RADIOACTIVE IODO-PLASMA PROTEIN 1

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Abstract
Plasma proteins tagged with radioactive I were used to study the capillary leakage hypothesis in hemorrhagic, tourniquet, and burn shock. No evidence of leakage due to a change in the permeability of the generalized capillary bed was found. Tagged plasma proteins escaped into areas of injury in considerable amts., but not into untraumatized areas. This was also true after plasma infusion. There is also evidence to show that the general capillary bed does not become more permeable to plasma proteins or plasma in the late or irreversible phase of hemorrhagic shock following transfusion. Following saline therapy in hemorrhagic shock, plasma proteins are carried out of the blood stream with saline. This occurs to a greater extent in irreversible than reversible hemorrhagic shock. The volume of dilute plasma lost in this way is small.