Serologic Comparison of Mammary Tumor Viruses from 3 Strains of Mice.

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Abstract
Possible antigenic differences were investigated by the technic of in vitro virus neutralization with rabbit antisera followed by injection into susceptible virus-free BALB/cCrgl mice. The viruses carried by 2 different strains of mice (A/Crgl and C3H/Crgl) were compared, as well as the viruses differing in effect upon tumor development age which are carried in a strain (A/Crgl) and a subline of it (A/Crgl/3). One strain (BALB/cCrgl) served as donor for all viruses, eliminating tissue antigen differences. A comparison was also made of one virus in antigenically different hosts (A/Crgl virus in A/Crgl and in BALB/cCrgl mice). Neutralization efficiency was measured by tumor incidence in the test mice. No antigenic differences were found. Normal rabbit serum and antiserum against virus-free BALB/cCrgl tissue did not neutralize the virus. Antiserum against any of the viruses neutralized that virus and all others tested. Neutralization of the virus was not affected by the tissue source of the virus.

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