High Intratumoral Accumulation of Stealth Liposomal Doxorubicin in Sarcomas: Rationale for Combination with Radiotherapy
- 1 January 2000
- journal article
- research article
- Published by Medical Journals Sweden AB in Acta Oncologica
- Vol. 39 (2) , 207-211
- https://doi.org/10.1080/028418600430789
Abstract
Sarcomas are radioresistant tumors, the only curative therapy being radical surgical resection. Stealth® liposomal doxorubicin (Caelyx®) is a novel drug formulation that allows prolonged circulation and high intratumoral concentration. This study investigates the concurrent use of radiotherapy with Caelyx® in a cohort of 7 patients with locally advanced or recurrent sarcoma. Radiotherapy was given as a standard fractionation regimen to a total dose of 70 Gy. Caelyx® was given as a 30-min infusion at a dose of 25 mg/m2Keywords
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