A metabolite of a structural analog of thalidomide lacks teratogenic effect in pregnant rhesus monkeys
- 1 October 1980
- journal article
- research article
- Published by Wiley in Teratology
- Vol. 22 (2) , 183-185
- https://doi.org/10.1002/tera.1420220207
Abstract
A metabolite of CG 3033, a structural analog of thalidomide, was examined for teratogenic potential in rhesus monkeys. The metabolite EM 240 is produced in man by hydrolysis of the parent compound but the pathway is absent in nonhuman primates. Fifteen mg/kg administered orally throughout organogenesis to pregnant rhesus monkeys produced no evidence of embryotoxicity, including malformation.This publication has 3 references indexed in Scilit:
- Comparative distribution and embryotoxicity of methotrexate in pregnant rats and rhesus monkeysTeratology, 1979
- Breeding and pregnancy in rhesus monkeys used for teratological testingTeratology, 1970
- Congenital malformations in nonhuman primates: Spontaneous and experimentally inducedThe Anatomical Record, 1967