Renaturation of DNA catalysed by yeast DNA repair and recombination protein RAD1O
- 1 February 1992
- journal article
- Published by Springer Nature in Nature
- Vol. 355 (6362) , 743-745
- https://doi.org/10.1038/355743a0
Abstract
The RAD10 gene of Saccharomyces cerevisiae is required for the incision step of excision repair of ultraviolet-damaged DNA, and it functions in mitotic recombination. RAD10 has homology to the human excision repair gene ERCC-1. Here we describe the purification of the protein encoded by RAD10 and show that it is a DNA-binding protein with a strong preference for single-stranded DNA. We also show that RAD10 promotes the renaturation of complementary DNA strands.Keywords
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