Optical resolution of 6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline by supercritical fluid extraction
- 25 September 2001
- Vol. 13 (9) , 568-570
- https://doi.org/10.1002/chir.1178
Abstract
6-Fluoro-2-methyl-1,2,3,4-tetrahydroquinoline (FTHQ) enantiomers were separated by supercritical fluid extraction using carbon dioxide. Diastereoisomeric salts were formed from the racemic base with less than one equivalent of O,O'-di-(4-toluoyl)-(2R,3R)-tartaric acid (DPTTA). Further purification was achieved by partial salt formation of the enantiomeric mixture with an achiral acid (HCl) followed by the supercritical fluid extraction of the free enantiomers.Keywords
Funding Information
- Ministry of Education and Culture (MKM, FKFP 0269/1997)
- Hungarian OTKA Foundation (T029251)
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