Hodgkin's Disease in Bone, with Special Reference to Periosteal Reaction

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Abstract
One hundred eight patients with Hodgkin''s disease showing bone lesions were studied to determine the frequency, sites and type of involvement. One hundred of these had at least a 5 year follow up. Bone lesions are generally evidence of widespread dissemination of the disease and are therefore of serious prognostic import; at least 60% of patients dying within 2 years of the appearance of their 1st bone lesion, and almost 80% within 3 years. The 5 year survival of patients after the development of a bone lesion is only 4. 25% in contrast to the general 5 year survival in this series of 41%. No particular type of bone lesion affected the prognosis. The incidence of periosteal reaction in this series was very high (29.5%) and this is a valuable diagnostic sign of Hodgkin''s disease, especially when it occurs on the lateral border of a vertebra.

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