Extracellular Potassium Accumulation and Inward-Going Potassium Rectification in Voltage Clamped Ventricular Muscle
- 9 January 1976
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 191 (4222) , 90-92
- https://doi.org/10.1126/science.1246599
Abstract
Measurements of afterpotential, action potential duration, and output of a potassium-sensitive microelectrode indicate that the application of long clamp pulses (1 to 8 seconds) to frog ventricular muscle is accompanied by a change in the extracellular potassium concentration. The plot of the magnitude of the potassium accumulation against the clamped membrane potential yields an N-shaped relation similar to the "steady state" current-voltage relation. The accumulation studies confirm a strong inward-going (anomalous) potassium rectification.Keywords
This publication has 7 references indexed in Scilit:
- Potassium ion accumulation in a periaxonal space and its effect on the measurement of membrane potassium ion conductanceThe Journal of Membrane Biology, 1973
- Excitation—contraction coupling in frog ventricle: evidence from voltage clamp studiesThe Journal of Physiology, 1971
- The efflux of potassium, sodium, chloride, calcium and sulphate ions and of sorbitol and glycerol during the cardiac cycle in frog's ventricleThe Journal of Physiology, 1968
- Intracellular sodium concentration and resting sodium fluxes of the frog heart ventricleThe Journal of Physiology, 1967
- The sodium‐potassium hypothesis as the basis of electrical activity in frog ventricleThe Journal of Physiology, 1960
- Shortening of the cardiac action potential due to a brief injection of KCl following the onset of activityThe Journal of Physiology, 1956
- The after‐effects of impulses in the giant nerve fibres of LoligoThe Journal of Physiology, 1956